Methoxamine HCL
methoxamine hydrochloride
CAS: 61-16-5
Molecular Formula: C11H18ClNO3
Methoxamine HCL - Names and Identifiers
| Name | methoxamine hydrochloride |
| Synonyms | vasoxyl Methoxamine HCL Diaveridine HCl vasoxylhydrochloride methoxamine hydrochloride Methoxamine Hydrochloride (200 mg) 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol.HCl MethoxaMine Hydrochloride (Mixture of DiastereoMers) 2-aMino-1-(2,5-diMethoxyphenyl)propan-1-ol hydrochloride α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride α-[1-Aminoethyl]-2,5-dimethoxybenzenemethanol hydrochloride |
| CAS | 61-16-5 |
| EINECS | 200-499-7 |
| InChI | InChI=1/C11H17NO3.2ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;;/h4-7,11,13H,12H2,1-3H3;2*1H |
Methoxamine HCL - Physico-chemical Properties
| Molecular Formula | C11H18ClNO3 |
| Molar Mass | 247.72 |
| Melting Point | 215℃ |
| Appearance | Solid |
| pKa | 9.2(at 25℃) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5204 |
Methoxamine HCL - Risk and Safety
| WGK Germany | 3 |
| RTECS | DN4025000 |
Methoxamine HCL - Standard
Authoritative Data Verified Data
This product is a-(l-aminoethyl)-2, 5-dimethoxybenzyl alcohol hydrochloride. The content of C11H17N03 • HC1 shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
Methoxamine HCL - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless or almost odorless.
- This product is soluble in water, soluble in ethanol, almost insoluble in chloroform or ether.
absorption coefficient
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 30ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 290nm, and the absorption coefficient was 133 to 141.
Last Update：2022-01-01 14:21:39
Methoxamine HCL - Differential diagnosis
Authoritative Data Verified Data
- take about 1 mg of this product, add 3 drops of formaldehyde and sulfuric acid test solution, which is purple, gradually Brown, and finally green.
- take about 20mg of this product, add 2ml of water, and add 0.5ml of silver nitrate test solution to generate white curd-like precipitate, which can be dissolved in ammonia test solution but insoluble in nitric acid.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 329).
Last Update：2022-01-01 14:21:39
Methoxamine HCL - Exam
Authoritative Data Verified Data
acidity
take 0.20g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.5~6.0.
ketoamine
take this product, add water to dissolve and dilute to make a solution containing about 0401 mg per lml, according to UV-visible spectrophotometry (general rule), at the wavelength of NM, the absorbance should not exceed 0.06.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the high performance liquid chromatography (General 0512) determination, with eighteen alkyl silane bonded silica gel as filler; 0.005mol/L sodium heptane sulfonate solution (with 0.1 mol/L hydrochloric acid solution to adjust the pH value to 3.5)-methanol (58:42) as mobile phase; The detection wavelength was 226mn. The number of theoretical plates shall not be less than 3000 calculated by methoxyl peak, and the degree of separation between methoxyl peak and adjacent impurity peak shall meet the requirements. 20 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry at 105°C for 2 hours, loss of weight shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.2% (General rule 0841).
Last Update：2022-01-01 14:21:40
Methoxamine HCL - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add water 50ml to dissolve, add nitric acid 1ml, according to the potential titration method (General rule 0701), with silver nitrate titration solution (0.lmol/L) titration, silver nitrate titration solution per lml (0.1 mol/L) corresponds to 24.77mg of C11H17N03. HCI.
Last Update：2022-01-01 14:21:41
Methoxamine HCL - Category
Authoritative Data Verified Data
a adrenoceptor agonists.
Last Update：2022-01-01 14:21:41
Methoxamine HCL - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 14:21:41
Methoxamine HCL - Methoxamine hydrochloride injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of methoxamine hydrochloride. Containing methoxamine hydrochloride (C11H17N03 • HC1) shall be between 95.0% and 105.0% of the label.
trait
This product is a clear colorless liquid.
identification
- Take 2~3 drops of this product, put it in a porcelain evaporation dish, steam dry on a water bath, let it cool, add 3 drops of formaldehyde sulfuric acid test solution, that is, purple, gradually Brown, finally turned green.
- take 1ml of this product and add 0.5ml of silver nitrate test solution, that is, a white curd-like precipitate occurs, which can be dissolved in the ammonia test solution, but insoluble in nitric acid.
examination
- the pH value should be 3.0 to 5.5 (General 0631).
- Related Substances: dilute the product with mobile phase to prepare a solution containing about 1 mg of methoxamine hydrochloride per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- bacterial endotoxin take this product, check according to law (General 1143), each 1 mg methoxamine hydrochloride containing endotoxin amount should be less than 7.5EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product (about equivalent to methoxamine hydrochloride lOOmg), put it in a 250ml measuring flask, dilute it with water to the scale, and shake it well; Take 10ml for precision measurement, set it in a 100ml measuring flask, dilute it to the scale with water, shake it well, and measure the absorbance at the wavelength of 290nm by UV-Vis spectrophotometry (General rule 0401), the absorption coefficient of C11H17N03. HC1 was calculated to be 137.
category
with methoxamine hydrochloride.
specification
(l ) lml:1Omg ( 2 ) lml:20mg
storage
sealed storage.
Last Update：2022-01-01 14:21:42
Methoxamine HCL - Reference Information
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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View History
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